Roger F Bone Selected Research

1- (N- (2- (Amidinoaminooxy)ethyl)amino)carbonylmethyl- 6- methyl- 3- (2,2- difluoro- 2- phenylethylamino)pyrazinone

2/2010

Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.

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Roger F Bone Research Topics

Disease

3	Reperfusion Injury 08/2012 - 06/2004
3	Hereditary Angioedemas 03/2008 - 06/2004
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 08/2012
1	Thrombosis (Thrombus) 02/2010
1	Venous Thrombosis (Deep-Vein Thrombosis) 02/2010
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 03/2008

Drug/Important Bio-Agent (IBA)

2	Complement System Proteins (Complement)IBA 03/2008 - 06/2004
1	Protease Inhibitors (Protease Inhibitor)IBA 08/2012
1	Complement C1s (C1 Esterase)IBA 08/2012
1	1- (N- (2- (Amidinoaminooxy)ethyl)amino)carbonylmethyl- 6- methyl- 3- (2,2- difluoro- 2- phenylethylamino)pyrazinoneIBA 02/2010
1	Thrombin FDA Link 02/2010
1	AntibodiesIBA 03/2008
1	Proteins (Proteins, Gene)FDA Link 03/2008
1	Complement Inactivating AgentsIBA 03/2008
1	Serine Proteases (Serine Protease)IBA 04/2006

Therapy/Procedure

1	Oral Administration 02/2010
1	Therapeutics 03/2008